Antioxidant therapy enhances pulpal healing in bleached teeth
Lima Adriano Fonseca, Marques Marcelo Rocha, Soares Diana Gabriela, Hebling Josimeri, Marchi Giselle Maria, Costa Carlos Alberto de Souza,
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( Lima Adriano Fonseca ) - Paulista University School of Dentistry Dental Research Division
( Marques Marcelo Rocha ) - University of Campinas Piracicaba Dental School Department of Morphology
( Soares Diana Gabriela ) - University Estadual Paulista Araraquara School of Dentistry Department of Physiology and Pathology
( Hebling Josimeri ) - University of Campinas Piracicaba Dental School Department of Restorative Dentistry
( Marchi Giselle Maria ) - University of Campinas Piracicaba Dental School Department of Restorative Dentistry
( Costa Carlos Alberto de Souza ) - University Estadual Paulista Araraquara School of Dentistry Department of Physiology and Pathology
KMID : 1034420160410010044
Abstract
Objectives: The purpose of this study was to evaluate the histopathological effects of an antioxidant therapy on the pulp tissue of rat teeth exposed to a bleaching gel with 35% hydrogen peroxide.
Materials and Methods: Forty rats were subjected to oral ingestion by gavage of distilled water (DW) or ascorbic acid (AA) 90 min before the bleaching therapy. For the bleaching treatment, the agent was applied twice for 5 min each to buccal surfaces of the first right mandibular molars. Then, the animals were sacrificed at 6 hr, 24 hr, 3 day, or 7 day post-bleaching, and the teeth were processed for microscopic evaluation of the pulp tissue.
Results: At 6 hr, the pulp tissue showed moderate inflammatory reactions in all teeth of both groups. In the DW and AA groups, 100% and 80% of teeth exhibited pulp tissue with significant necrosis and intense tissue disorganization, respectively. At 24 hr, the AA-treated group demonstrated a greater regenerative capability than the DW group, with less intense inflammatory reaction and new odontoblast layer formation in 60% of the teeth. For up to the 7 day period, the areas of pulpal necrosis were replaced by viable connective tissue, and the dentin was underlined by differentiated odontoblast-like cells in most teeth of both groups.
Conclusions: A slight reduction in initial pulpal damage during post-bleaching was promoted by AA therapy. However, the pulp tissue of AA-treated animals featured faster regenerative potential over time.
키워드
Ascorbic acid; Dental pulp; Hydrogen peroxide; Tooth bleaching
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